Delta-9-THC-11-oic acid glucuronide methyl ester is a methylated derivative of Delta-9-THC-11-oic acid glucuronide, which is a metabolite of Delta-9-tetrahydrocannabinol (Delta-9-THC), the primary psychoactive compound in cannabis. Methyl ester derivatives are formed by the addition of a methyl group to the carboxylic acid group of the glucuronide metabolite.
The addition of a methyl group enhances the stability and lipophilicity of the metabolite, making it more resistant to further enzymatic breakdown and potentially increasing its potency or duration of action. This modification may affect the pharmacokinetics and pharmacodynamics of the metabolite within the body.
The methyl ester derivative of Delta-9-THC-11-oic acid glucuronide is primarily formed through enzymatic processes in the liver. After formation, it can be further metabolized or eliminated from the body through urine or feces.
Research on the specific properties and effects of Delta-9-THC-11-oic acid glucuronide methyl ester is limited, and its pharmacological significance in relation to Delta-9-THC metabolism and cannabis use is not well understood. Further studies are needed to explore its role and potential implications.